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Article

Prioritization of novel druggable targets for epilepsy via Mendelian randomization and colocalization.

Behavioural brain research - 8 May 2026

Li Dong, Ma Yazhou, Chen Xin, Zhou Feifan, Xu Yuhua, Lian Xuegan

Abstract excerpt

Epilepsy is clinically heterogeneous and frequently drug-resistant, motivating genetics-informed target prioritization with clinical tractability. Two-sample Mendelian randomization using whole-blood cis-eQTL instruments estimated associations between genetically proxied gene expression and the odds of epilepsy in FinnGen R11 (14,089 cases). For MR-prioritized genes, Bayesian colocalization assessed whether eQTL...

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Source

Identifiers

PMID: 41698610
DOI: 10.1016/j.bbr.2026.116081

Genes

ADORA1
CLEC3B
CXCR6
EP300
TKT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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