Article
Identification of breast cancer susceptibility genes via trans-ethnic Mendelian randomization and colocalization analyses.
Medicine - 5 Dec 2025
Huang Ke, Huang Hui, Ma Lin-Lin, Liu Yan, Li Qing
Abstract excerpt
Breast cancer remains a major global health burden, with persistent challenges including recurrence, metastasis, and drug resistance limiting the efficacy of current treatments. The identification of novel therapeutic targets is essential for advancing precision oncology. We employed a 2-sample Mendelian randomization (MR) framework utilizing large-scale eQTL and genome-wide association study (GWAS) datasets from...
Topics
- Humans
- Breast Neoplasms
- Mendelian Randomization Analysis
- Female
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Molecular Docking Simulation
- Protein Interaction Maps
- Quantitative Trait Loci
- Polymorphism, Single Nucleotide