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Article

Identification of breast cancer susceptibility genes via trans-ethnic Mendelian randomization and colocalization analyses.

Medicine - 5 Dec 2025

Huang Ke, Huang Hui, Ma Lin-Lin, Liu Yan, Li Qing

Abstract excerpt

Breast cancer remains a major global health burden, with persistent challenges including recurrence, metastasis, and drug resistance limiting the efficacy of current treatments. The identification of novel therapeutic targets is essential for advancing precision oncology. We employed a 2-sample Mendelian randomization (MR) framework utilizing large-scale eQTL and genome-wide association study (GWAS) datasets from...

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Source

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Identifiers

PMID: 41367007
DOI: 10.1097/MD.0000000000045751
PMCID: PMC12689003

Genes

CBX6
DNPH1
FAAH
LAMB2
RCCD1
SLC22A5
SYT11

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