Article

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

2018-09-09

Abstract excerpt

Trio family and case-control studies of next-generation sequencing data have proven integral to understanding the contribution of rare inherited and de novo single-nucleotide variants to the genetic architecture of complex disease. Ideally, such studies should identify individual risk genes of moderate to large effect size to generate novel treatment hypotheses for further follow-up. However, due to insufficient...

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Literature Corpus work: ebd6fcdd-a4df-52d7-bce5-25976b2b3a8f
DOI: 10.1101/410100

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