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Article

Leveraging pQTL-based Mendelian randomization to identify new treatment prospects for primary biliary cholangitis and primary sclerosing cholangitis.

Aging - 27 May 2024

Dai Lei, Ye Yunyan, Mugaany Joseph, Hu Zetong, Huang Jing, Lu Changjiang

Abstract excerpt

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are autoimmune disorders characterized by progressive and chronic damage to the bile ducts, presenting clinicians with significant challenges. The objective of this study is to identify potential druggable targets to offer new avenues for treatment. A Mendelian randomization analysis was performed to identify druggable targets for PBC and...

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Share to Cholangitis, Sclerosing
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis, Biliary

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 38809509
DOI: 10.18632/aging.205867
PMCID: PMC11164478

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