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Article

TiRank prioritizes phenotypic niches in tumor microenvironment for clinical biomarker discovery.

Genome medicine - 13 Feb 2026

Lin Yuxiang, Huang Zening, Lin Ziyan, Lin Yating, Song Jinsheng, Luo Ling, Chi Jiayao, Zheng Yeyang, Gao Youxin, Lin Junjie, Li Xinyu, Liang Chenyu, Zhang Lei, Wang Xinkang, Sun Yuqin, Yu Rongshan, Chen Qiyue, Tong Mengsha

Abstract excerpt

BACKGROUND: Tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and treatment response. Recent advances in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have provided valuable insights into the cellular diversity and spatial organization of the TME. However, prioritizing clinically relevant cellular subpopulations in spatial contexts using...

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PMID: 41689080
DOI: 10.1186/s13073-026-01604-2
PMCID: PMC12910759

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