Article

Spatial multi-omics and deep learning reveal fingerprints of immunotherapy response and resistance in hepatocellular carcinoma

2025-06-13

Abstract excerpt

Despite advances in immunotherapy treatment, nonresponse rates remain high, and mechanisms of resistance to checkpoint inhibition remain unclear. To address this gap, we performed spatial transcriptomic and proteomic profiling on human hepatocellular carcinoma tissues collected before and after immunotherapy. We developed an interpretable, multimodal deep learning framework to extract key cellular and molecular si...

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Literature Corpus work: e5986e2b-20ad-505b-b49e-795e08b21624
DOI: 10.1101/2025.06.11.656869

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