Article

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition

2025-01-28

Abstract excerpt

Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the determinants of response remain largely unknown. To better understand the factors influencing patient outcome, we assembled a longitudinal cohort with tissue from multiple timepoints, including primary tumor, pre-treatment...

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Literature Corpus work: 487e791d-98ee-5bb1-b0ae-7b104e2780cf
DOI: 10.1101/2025.01.26.634557

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