Article

Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes

2023-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Over 10% of type 1 diabetes (T1D) cases do not have high-risk HLA-DR3 or DR4 haplotypes with distinct clinical features such as later onset and reduced insulin dependence. To identify genetic drivers of T1D in the absence of DR3/DR4, we performed association and fine-mapping analyses in 12,316 non-DR3/DR4 samples. Risk variants at the MHC and other loci genome-wide had heterogeneity in effects on...

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Literature Corpus work: 508064b9-9bcd-5dc6-8e58-fe43d2ca471d
DOI: 10.1101/2023.11.11.23298405

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