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Article

The Novel Soluble Guanylate Cyclase Stimulator Attenuates Acute Lung Injury via Inhibiting Pericyte Phenotypic Transition.

International journal of molecular sciences - 29 Jan 2026

Huang Yu-Long, Li Shuo, Li Xia, Zhang Jin-Shui, Shi Ying-Xian, Su Gui-Xin, Zhang Yang, Xue Rui, Li Jing-Cao, Fan Qiong-Yin, Zheng Zhi-Bing, Deng Yun, Zhang You-Zhi

Abstract excerpt

Acute lung injury (ALI) pathogenesis is intricately linked to microvascular permeability. Soluble guanylate cyclase (sGC) is prominently expressed in the vascular system, playing a central role in vascular function. In contrast, its expression and function diminish notably during the progression of ALI, indicating sGC's potential significance as a pivotal modulator in the pathological processes of ALI....

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Identifiers

PMID: 41683771
DOI: 10.3390/ijms27031346
PMCID: PMC12897666

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