Article

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation

2021-11-15

Abstract excerpt

<h4>Aim</h4> The role of platelets in atherosclerosis remains incompletely understood. Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk. Here we sought to investigate the contribution of platelet sGC to atherosclerosis and the therapeutic potential of targeting sGC in atherosclerosis. <h4>Methods and Results</h4> We genetically dele...

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Literature Corpus work: aab84558-f394-578d-a697-99079a5ee597
DOI: 10.1101/2021.11.15.467680

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