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Article

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

Cardiovascular research - 1 Mar 2017

Duluc Lucie, Ahmetaj-Shala Blerina, Mitchell Jane, Abdul-Salam Vahitha B, Mahomed Abdul S, Aldabbous Lulwah, Oliver Eduardo, Iannone Lucio, Dubois Olivier D, Storck Elisabeth M, Tate Edward W, Zhao Lan, Wilkins Martin R, Wojciak-Stothard Beata

Abstract excerpt

Aims: RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect. Methods and results: The analysis of lung tissues from rodent models and pulmonary hypertensive patients showed increased levels of protein farnesylation. Oral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28395021
DOI: 10.1093/cvr/cvw258
PMCID: PMC5408956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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