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Article

Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implications

2023-04-11

Abstract excerpt

Nitric oxide (NO) is a widely distributed gasotransmitter binding to the heme of soluble guanylate cyclase (sGC) to stimulate the formation of the second messenger cyclic GMP. In disease, two pathomechanisms can occur, scavenging of NO by reactive oxygen species so that sGC is insufficiently stimulated, and oxidative damage of sGC resulting in heme loss and a NO-insensitive apo-form of sGC. To address this therape...

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Literature Corpus work
db0372e8-487f-5c90-83af-6ca33e739961
DOI
10.14293/s2199-1006.1.sor-.ppw9ffl.v2
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Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implicationsDOI 10.14293/s2199-1006.1.sor-.ppw9ffl.v2
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