Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol

Abstract excerpt

Antibiotic resistance poses a global public health threat. Cefiderocol, a recently introduced siderophore cephalosporin, employs a “Trojan Horse” mechanism by exploiting bacterial iron uptake systems for cell entry. Yet, resistant clinical isolates are already observed in clinics and resistance mechanisms are difficult to characterize. Here, we applied functional metagenomics to identify cefiderocol resistance gen...

Topics

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• Acinetobacter baumannii
• Cephalosporins
• Drug Resistance, Bacterial
• Drug Resistance, Multiple, Bacterial
• Klebsiella pneumoniae
• Microbial Sensitivity Tests
• Pseudomonas aeruginosa
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

fab71f78-3594-5144-85b6-e26f7e2cd90d

DOI

10.1101/2025.05.26.656069