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Cefiderocol in Combating Carbapenem-Resistant Acinetobacter baumannii: Action and Resistance

6 Nov 2024

Abstract excerpt

Acinetobacter baumannii (A. baumannii) has emerged as a prominent multidrug-resistant (MDR) pathogen, significantly complicating treatment strategies due to its formidable resistance mechanisms, particularly against carbapenems. Reduced membrane permeability, active antibiotic efflux, and enzymatic hydrolysis via different β-lactamases are the main resistance mechanisms displayed by A. baumannii, and they are all...

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PMID: 39595098
DOI: 10.3390/biomedicines12112532

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