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Article

Emergence of cefiderocol resistance mediated by blaAFM-1 overexpression and FptA mutations in clinical carbapenem-resistant Pseudomonas aeruginosa isolates.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2026

Xiao Yanghua, Zhang Jingwen, Nie Feng, Li Ping, Li Keyi, Tao Xingyu, Zheng Fanglin, Zhao Rui, Zhang Wei

Abstract excerpt

OBJECTIVES: This study evaluated the in vitro activity of cefiderocol against clinical carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates in China before its clinical introduction, and investigated the mechanisms underlying resistance. METHODS: A total of 557 nonduplicate CRPA isolates were collected from central China between 2021 and 2024. Antimicrobial susceptibility testing, whole-genome sequencing,...

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PMID: 41429346
DOI: 10.1016/j.cmi.2025.12.011

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AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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