Molecular characteristics of chromosome-mediated colistin resistance in carbapenem-resistant Pseudomonas aeruginosa isolates from a tertiary hospital in China.

Abstract excerpt

BACKGROUND: This study aimed to investigate the prevalence and underlying mechanisms of colistin resistance among 557 non-duplicate CRPA isolates collected from a tertiary hospital in Jiangxi, China, between 2021 and 2024. METHODS: Antimicrobial susceptibility testing, whole-genome sequencing, bioinformatic analyses, site-directed mutagenesis, RT-qPCR and time-kill kinetics assay were performed to investigate the...

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