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Article

Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.

European journal of nuclear medicine and molecular imaging - 1 May 2026

Li Jian, Guo Xuan, Xiang Yaqin, Huang Juanjuan, Mu Wenna, Ma Qiaoke, Tang Yongxiang, Tang Beisha, Guo Jifeng, Hu Shuo

Abstract excerpt

PURPOSE: To map whole-brain dopamine transporter (DAT) depletion patterns in Parkinson’s disease (PD) using 11C-CFT PET and evaluate their utility in distinguishing tremor-dominant (TD) and postural instability/gait difficulty (PIGD) subtypes in early PD. METHODS: This retrospective study included 197 PD patients (80 TD, 117 PIGD) and 21 healthy controls. 11C-CFT PET quantified DAT availability across...

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PMID: 41656420
DOI: 10.1007/s00259-026-07779-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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