Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease.

Neurobiology of aging - 1 Jan 2021

Sampedro Frederic, Marín-Lahoz Juan, Martínez-Horta Saul, Camacho Valle, Lopez-Mora Diego-Alfonso, Pagonabarraga Javier, Kulisevsky Jaime

Abstract excerpt

Striatal dopamine transporter (DAT) uptake assessment through I123-Ioflupane Single-Pphoton Emission Computed Tomography (SPECT) provides valuable information about the dopaminergic denervation occurring in Parkinson's disease (PD). However, little is known about the clinical or biological relevance of extrastriatal DAT uptake in PD. Here, from the Parkinson's Progression Markers Initiative, we studied 623...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Dopamine Plasma Membrane Transport Proteins

Share to Iodine Radioisotopes

Share to Parkinson Disease

Share to Radiopharmaceuticals

Share to Tomography, Emission-Computed, Single-Photon

Source

Identifiers

PMID: 33212336
DOI: 10.1016/j.neurobiolaging.2020.10.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease.PMID 33212336Read ↗

Neuroimaging Biomarkers in Parkinson's Disease: Current Applications and Future DirectionsSemantic proximity Read ↗

Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.Semantic proximity Read ↗

Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathiesSemantic proximity Read ↗

Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression.Semantic proximity Read ↗

Striatal dopamine transporter uptake predicts neuronal hypometabolism and visuospatial function in Parkinson’s diseaseSemantic proximity Read ↗

Reliability of Dopamine Transporter PET Measurements with [18F]FE-PE2I in patients with Parkinson´s DiseaseSemantic proximity Read ↗

Loss of serotonergic function in carriers of PRKN mutations: a [11C]DASB PET study.Semantic proximity Read ↗

Longitudinal decline in striatal dopamine transporter binding in Parkinson’s disease: Associations with apathy and anhedoniaSemantic proximity Read ↗

The role of biomarkers and imaging in Parkinson's disease.Semantic proximity Read ↗

Neuroanatomical substrates in Parkinson’s Disease psychosis and their association with serotonergic receptor gene expression: A coordinate-based meta-regression analysisSemantic proximity Read ↗

Transporter Single Photon Emission Computed Tomography (DaT-SPECT) use in The Diagnosis and Clinical Management of Parkinsonism: An Eight-Year Retrospective StudySemantic proximity Read ↗

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.