Article
The noradrenergic subtype of Parkinson disease: from animal models to clinical practice.
Nature reviews. Neurology - 1 Jun 2023
Ray Chaudhuri K, Leta Valentina, Bannister Kirsty, Brooks David J, Svenningsson Per
Abstract excerpt
Many advances in understanding the pathophysiology of Parkinson disease (PD) have been based on research addressing its motor symptoms and phenotypes. Various data-driven clinical phenotyping studies supported by neuropathological and in vivo neuroimaging data suggest the existence of distinct non-motor endophenotypes of PD even at diagnosis, a concept further strengthened by the predominantly non-motor spectrum...
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