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Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease

9 Feb 2026

Abstract excerpt

BACKGROUND: Trimethylamine N-oxide (TMAO) and its related metabolites have been linked to cardiovascular disease (CVD), but their impact on DNA methylation remains unclear. Investigating these relationships may clarify the role of epigenetic mechanisms in diseases. METHODS: This study analyzed data from 1,356 adults from the Cardiovascular Health Study (CHS) and the Multi-Ethnic Study of Atherosclerosis (MESA)....

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PMID: 41656272
DOI: 10.1186/s13148-026-02060-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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