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Article

Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2014

Hartiala Jaana, Bennett Brian J, Tang W H Wilson, Wang Zeneng, Stewart Alexandre F R, Roberts Robert, McPherson Ruth, Lusis Aldons J, Hazen Stanley L, Allayee Hooman

Abstract excerpt

OBJECTIVE: Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goal of this study was to identify the genetic factors associated with plasma TMAO levels. APPROACH AND RESULTS: We used comparative...

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Source

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Identifiers

PMID: 24675659
DOI: 10.1161/ATVBAHA.114.303252
PMCID: PMC4035110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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