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Article

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease.

Nature communications - 29 Jan 2016

Hartiala Jaana A, Tang W H Wilson, Wang Zeneng, Crow Amanda L, Stewart Alexandre F R, Roberts Robert, McPherson Ruth, Erdmann Jeanette, Willenborg Christina, Hazen Stanley L, Allayee Hooman

Abstract excerpt

Metabolites derived from dietary choline and L-carnitine, such as trimethylamine N-oxide and betaine, have recently been identified as novel risk factors for atherosclerosis in mice and humans. We sought to identify genetic factors associated with plasma betaine levels and determine their effect on risk of coronary artery disease (CAD). A two-stage genome-wide association study (GWAS) identified two significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 26822151
DOI: 10.1038/ncomms10558
PMCID: PMC4740183

Genes

CAD
CPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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