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Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters

7 Dec 2016

Abstract excerpt

Trimethylamine-N-oxide (TMAO) is a recently identified predictor of cardiovascular and chronic kidney disease. TMAO is primarily generated through gut-microbiome mediated conversion of dietary choline and carnitine to TMA, which is converted to TMAO by hepatic flavin monooxygenase 3 (FMO3) and subsequently undergoes renal elimination. We investigated the role of uptake and efflux drug transporters in TMAO...

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PMID: 27977217
DOI: 10.1021/acs.molpharmaceut.6b00937

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