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Article

Trimethylamine N-oxide and its precursors in relation to blood pressure: A mendelian randomization study

22 Jul 2022

Abstract excerpt

Objective Previous studies have demonstrated that trimethylamine N-oxide (TMAO) and its precursors, including choline, betaine, and carnitine, are closely associated with blood pressure (BP) changes. Nevertheless, with the limitation of reverse causality and confounder in observational studies, such a relationship remains unclear. We aimed to assess the causal relationship of TMAO and its precursors with BP by...

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PMID: 35935641
DOI: 10.3389/fcvm.2022.922441

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