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Article

The role of polygenic risk in Alzheimer's disease prediction for African Americans.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2026

Hutten Christina G, Beck Todd, Evans Denis, Rajan Kumar B

Abstract excerpt

INTRODUCTION: African Americans (AAs) face a higher risk of Alzheimer's disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored. METHODS: A standardized dementia PRS was evaluated in the Chicago Health and Aging Project (n = 4336; 61% AA) for associations with ADRD and cognitive trajectories over 8.4 years. RESULTS: PRS...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42552753
DOI: 10.1002/alz.71712
PMCID: PMC13438189

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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