Liver Steatosis-Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication.

doi:10.1111/apt.70566

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Article

Liver Steatosis-Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication.

Alimentary pharmacology & therapeutics - 1 May 2026

Lin Yu-Sheng, Lin Ying-Cheng, Chen Yun-Yu, Chen Yi-Ming, Chen I-Chieh, Tsai Hsin-Ju, Chen Chia-Chang, Lee Shou-Wu, Yang Hwai-I, Lee Teng-Yu

Abstract excerpt

BACKGROUND AND AIMS: Genetic predisposition to hepatic steatosis may increase hepatocellular carcinoma (HCC) risk after hepatitis C virus (HCV) eradication in cirrhotic patients; however, its impact on broader patient populations remains unexplored. We aimed to evaluate the association of steatosis-polygenic risk score (PRS) with HCC following direct-acting antiviral (DAA) therapy. METHODS: This retrospective...

Topics

Humans
Carcinoma, Hepatocellular
Female
Male
Liver Neoplasms
Retrospective Studies
Genetic Risk Score
Antiviral Agents
Middle Aged
Aged
Taiwan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fatty Liver

Hepatitis C, Chronic

Risk Factors

Genetic Predisposition to Disease

Genotype

Incidence

Proportional Hazards Models

Source

Open in PubMed

Identifiers

PMID: 41655131
DOI: 10.1111/apt.70566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41655131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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