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Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies.

Gastroenterology - 1 Sept 2025

Xue Hongliang, Wang Liqing, Sun Dianjianyi, Wu Yuankai, Yu Canqing, Huang Yating, Chan Sun On, Ling Wenhua, Lv Jun, Li Liming, Chen Xu, Pang Yuanjie, Yu Chao

Abstract excerpt

BACKGROUND & AIMS: The new classification for steatotic liver disease identifies 3 phenotypes based on alcohol consumption. The aim of this study was to evaluate the associations between alcohol intake and liver-related events (LREs) across different drinking categories and whether genetic predisposition influences these associations. METHODS: Data from 301,673 UK Biobank participants were analyzed. Alcohol...

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PMID: 40379147
DOI: 10.1053/j.gastro.2025.04.021

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