Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

doi:10.1016/j.jhep.2020.11.024

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

Journal of hepatology - 1 Apr 2021

Bianco Cristiana, Jamialahmadi Oveis, Pelusi Serena, Baselli Guido, Dongiovanni Paola, Zanoni Irene, Santoro Luigi, Maier Silvia, Liguori Antonio, Meroni Marica, Borroni Vittorio, D'Ambrosio Roberta, Spagnuolo Rocco, Alisi Anna, Federico Alessandro, Bugianesi Elisabetta, Petta Salvatore, Miele Luca, Vespasiani-Gentilucci Umberto, Anstee Quentin M, Stickel Felix, Hampe Jochen, Fischer Janett, Berg Thomas, Fracanzani Anna Ludovica, Soardo Giorgio, Reeves Helen, Prati Daniele, Romeo Stefano, Valenti Luca

Abstract excerpt

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into the causal relationship between NAFLD and HCC, and to improve HCC risk stratification. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Europe

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to Mediation Analysis

Share to Multifactorial Inheritance

Share to Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 33248170
DOI: 10.1016/j.jhep.2020.11.024
PMCID: PMC7987554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.PMID 33248170Read ↗

A Polygenic Risk Score to Refine Risk Stratification and Prediction for Severe Liver Disease by Clinical Fibrosis ScoresSemantic proximity Read ↗

Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy.Semantic proximity Read ↗

Update on NAFLD genetics: From new variants to the clinic.Semantic proximity Read ↗

Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications.Semantic proximity Read ↗

Monogenic and Polygenic Risk in Common Liver Diseases: Implications for Clinical Care.Semantic proximity Read ↗

The risk stratification and predictive performance of a new combined polygenic risk score for hepatocellular carcinoma.Semantic proximity Read ↗

Advances in the genetics of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Hepatic Fat-Genetic Risk Score Predicts Hepatocellular Carcinoma in Patients With Cirrhotic HCV Treated With DAAs.Semantic proximity Read ↗

Liver Steatosis-Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication.Semantic proximity Read ↗

A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.Semantic proximity Read ↗

Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.Semantic proximity Read ↗

The Health Impact of MAFLD, a Novel Disease Cluster of NAFLD, Is Amplified by the Integrated Effect of Fatty Liver Disease-Related Genetic Variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.