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Article

The risk stratification and predictive performance of a new combined polygenic risk score for hepatocellular carcinoma.

Journal of gastroenterology - 1 Nov 2024

Yu Chengxiao, Tang Yuchen, Liu Maojie, Xu Xin, Ge Xinyuan, Ma Hongxia, Jin Guangfu, Shen Hongbing, Song Ci, Hu Zhibin

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWASs) in liver diseases have generated some polygenic risk scores (PRSs), but their predictive effectiveness on hepatocellular carcinoma (HCC) risk assessment remains unclear. METHODS: Here, we constructed a novel combined polygenic risk score and evaluated its increment to the well-established risk model. We used 15 HCC-associated genetic loci from two PRSs...

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Identifiers

PMID: 39126459
DOI: 10.1007/s00535-024-02144-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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