The risk stratification and predictive performance of a new combined polygenic risk score for hepatocellular carcinoma.

doi:10.1007/s00535-024-02144-5

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Article

The risk stratification and predictive performance of a new combined polygenic risk score for hepatocellular carcinoma.

Journal of gastroenterology - 1 Nov 2024

Yu Chengxiao, Tang Yuchen, Liu Maojie, Xu Xin, Ge Xinyuan, Ma Hongxia, Jin Guangfu, Shen Hongbing, Song Ci, Hu Zhibin

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWASs) in liver diseases have generated some polygenic risk scores (PRSs), but their predictive effectiveness on hepatocellular carcinoma (HCC) risk assessment remains unclear. METHODS: Here, we constructed a novel combined polygenic risk score and evaluated its increment to the well-established risk model. We used 15 HCC-associated genetic loci from two PRSs...

Topics

Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Genome-Wide Association Study
Male
Female
Middle Aged
Risk Assessment
Aged
Genetic Predisposition to Disease
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Adult

Predictive Value of Tests

Cohort Studies

Polymorphism, Single Nucleotide

Genetic Risk Score

Source

Open in PubMed

Identifiers

PMID: 39126459
DOI: 10.1007/s00535-024-02144-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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