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Genetic variants underlying precancerous conditions of hepatocellular carcinoma

20 Aug 2025

Abstract excerpt

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD) to HCC development. Genetic predispositions play a crucial role...

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PMID: 40833357
DOI: 10.1002/ijc.70092

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