Article
Identification of 13 Novel Loci in a Genome-Wide Association Study on Taiwanese with Hepatocellular Carcinoma.
International journal of molecular sciences - 16 Nov 2023
Liu Ting-Yuan, Liao Chi-Chou, Chang Ya-Sian, Chen Yu-Chia, Chen Hong-Da, Lai I-Lu, Peng Cheng-Yuan, Chung Chin-Chun, Chou Yu-Pao, Tsai Fuu-Jen, Jeng Long-Bin, Chang Jan-Gowth
Abstract excerpt
Liver cancer is caused by complex interactions among genetic factors, viral infection, alcohol abuse, and metabolic diseases. We conducted a genome-wide association study and polygenic risk score (PRS) model in Taiwan, employing a nonspecific etiology approach, to identify genetic risk factors for hepatocellular carcinoma (HCC). Our analysis of 2836 HCC cases and 134,549 controls revealed 13 novel associated loci...
Topics
- Humans
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Genome-Wide Association Study
- Risk Factors
- Virus Diseases
- Genetic Predisposition to Disease