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Decanoic Acid Treatment Alleviates Non-cell Autonomous Transfer of HD Pathology by Secretome of Mutant Huntingtin Expressing Cells.

Neurochemical research - 7 Feb 2026

Mehta Ragi, Dabhi Rajubhai, Singh Sushmita, Shah Anjali, Vijayvargia Ravi

Abstract excerpt

Huntington’s disease (HD) is a fatal neurodegenerative disorder marked by progressive neuronal loss with prominent degeneration of the striatum. Although classically viewed as a cell-autonomous disorder, emerging evidence suggest non-cell-autonomous spread of the pathology but without clear mechanistic details. In this study, we demonstrate that the secretome of a truncated mHTT expressing HD150Q cells contains...

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PMID: 41653326
DOI: 10.1007/s11064-026-04691-0

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BDNF
DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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