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Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin

14 Jun 2018

Abstract excerpt

The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyglutamine (polyQ) repeat at HTT's N-terminus. Neuronal pathology in HD is largely due to the toxic...

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PMID: 29904030
DOI: 10.3390/cells7060059

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