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Article

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.

Neuron - 9 Sept 2020

Lee Hyeseung, Fenster Robert J, Pineda S Sebastian, Gibbs Whitney S, Mohammadi Shahin, Davila-Velderrain Jose, Garcia Francisco J, Therrien Martine, Novis Hailey S, Gao Fan, Wilkinson Hilary, Vogt Thomas, Kellis Manolis, LaVoie Matthew J, Heiman Myriam

Abstract excerpt

The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in Huntington's disease (HD) are not fully understood. To gain new molecular insights, we used single nuclear RNA sequencing (snRNA-seq) and translating ribosome affinity purification (TRAP) to conduct transcriptomic analyses of caudate/putamen (striatal) cell type-specific gene expression changes in human HD and mouse models of HD. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32681824
DOI: 10.1016/j.neuron.2020.06.021
PMCID: PMC7486278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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