Article
Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's disease in vitro model.
The European journal of neuroscience - 1 Aug 2016
Lee Mijung, Liu Tian, Im Wooseok, Kim Manho
Abstract excerpt
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by the aggregation of mutant Huntingtin (mHtt). Adipose-derived stem cells (ASCs) have a potential for use in the treatment of incurable disorders, including HD. ASCs secrete various neurotrophic factors and microvesicles, and modulate hostile microenvironments affected by disease through paracrine mechanisms. Exosomes are small vesicles...
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