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Article

High prevalence of phenotypic pyrazinamide resistance and its association with pncA gene mutations in Mycobacterium tuberculosis isolates from Uganda.

PloS one - 1 Jan 2020

Naluyange Resty, Mboowa Gerald, Komakech Kevin, Semugenze Derrick, Kateete David Patrick, Ssengooba Willy

Abstract excerpt

INTRODUCTION: Susceptibility testing for pyrazinamide (PZA), a cornerstone anti-TB drug is not commonly done in Uganda because it is expensive and characterized with technical difficulties thus resistance to this drug is less studied. Resistance is commonly associated with mutations in the pncA gene and its promoter region. However, these mutations vary geographically and those conferring phenotypic resistance...

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Identifiers

PMID: 32413052
DOI: 10.1371/journal.pone.0232543
PMCID: PMC7228079

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