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Article

Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues.

American journal of human genetics - 5 Feb 2026

van der Graaf Adriaan, Rizi Sadegh, Auwerx Chiara, Kutalik Zoltán

Abstract excerpt

Reactions between metabolites are catalyzed by enzymes. These biochemical reactions form complex metabolic networks, which are only partially characterized in humans and whose regulation remains poorly understood. Here, we assess human biochemical reactions and regulation using Mendelian randomization (MR), a genetic observational causal inference technique, to understand the methods' strengths and weaknesses in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41650937
DOI: 10.1016/j.ajhg.2025.12.013
PMCID: PMC13087421

Genes

IL1RAP
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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