Mendelian randomization linking metabolites with enzymes reveals known and novel pathway regulation and therapeutic avenues

Abstract excerpt

Reactions between metabolites are catalyzed by enzymes. These biochemical reactions form complex metabolic networks, which are only partially characterized in humans and whose regulation remains poorly understood. Here, we assess human biochemical reactions and regulation using Mendelian randomization (MR), a genetic observational causal inference technique to understand the methods’ strengths and weaknesses in id...

Topics

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• CpG Islands
• Disease
• Enzymes
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Metabolic Networks and Pathways
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

8f352c7e-acb9-5553-b73c-0cf56f70f693

DOI

10.1101/2025.07.29.25332349