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Article

Metabolomic insights into pulmonary fibrosis: a mendelian randomization study.

BMC pulmonary medicine - 6 Jun 2024

Tang Wuyinuo, Jiang Huanyu, Wu Xinhui, Wu Guanyi, Zhao Chenchong, Lin Wenbo, Zhu Ying, Jiang Guowei, Chen Xiuhua, Huang Hang, He Lvyuan

Abstract excerpt

BACKGROUND: This study leverages a two-sample Mendelian Randomization (MR) approach to explore the causal relationships between 1,400 metabolites and pulmonary fibrosis, using genetic variation as instrumental variables. By adhering to stringent criteria for instrumental variable selection, the research aims to uncover metabolic pathways that may influence the risk and progression of pulmonary fibrosis, providing...

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Identifiers

PMID: 38844923
DOI: 10.1186/s12890-024-03079-6
PMCID: PMC11155030

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