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Article

Mutant huntingtin expression in somatostatin-positive interneurons contributes to neurophysiological and behavioral phenotypes in BACHD mice.

Disease models & mechanisms - 1 Mar 2026

Fowler Jahmel A, Scarduzio Mariangela, Pool Cayla, Mahan Casey D, Gray Michelle

Abstract excerpt

Huntington's disease (HD) is caused by expansion of the polyglutamine stretch in the widely expressed huntingtin (HTT) protein. Patients with HD have motor, psychiatric and cognitive changes due to changes in a variety of neural circuits. Somatostatin-expressing interneurons (SST-INs) can regulate neural circuits largely by inhibiting their target cells. Behaviorally, brain-wide inhibition of SST-INs increased...

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Identifiers

PMID: 41648922
DOI: 10.1242/dmm.052513
PMCID: PMC13054931

Genes

SST
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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