Article

Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington’s disease

2021-11-23

Abstract excerpt

<title>Abstract</title> <p>Huntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in the huntingtin gene. Although corticostriatal dysfunction has long been implicated in HD, the determinants and pathway specificity of this pathophysiology remain a matter of speculation. To help fill this gap, the zQ175+/- knockin mouse model of HD was studied using approaches that...

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Literature Corpus work: 89aa2177-8113-5d8d-bd57-8c5bb37f9da1
DOI: 10.21203/rs.3.rs-1008365/v1

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