Article

Somatostatin-positive Interneurons Contribute to Seizures in <i>SCN8A</i> Epileptic Encephalopathy

2021-02-07

Abstract excerpt

SCN8A epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant SCN8A which encodes the voltage-gated sodium channel Na V 1.6. To date, it is unclear if and how inhibitory interneurons, which express Na V 1.6, influence disease pathology. We found that selective expression of the R1872W mutation in somatostatin (SST) interneurons was sufficient to convey susceptibility to audiogenic seizures....

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Literature Corpus work: ef07afe8-95c0-5646-8865-83264dae86bf
DOI: 10.1101/2021.02.05.429987

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