Decoding efficacy and resistance space at a drug binding site.

Abstract excerpt

Assessing and understanding the impacts of all possible mutations at a drug binding site remain challenging. Here we use multiplex oligo targeting for mutational profiling, and computational modelling, to decode efficacy and resistance space at the otherwise native binding site for an anti-trypanosomal proteasome inhibitor. We saturation-edit twenty codons in the Trypanosoma brucei proteasome and subject the...

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