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Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

1 Jan 2020

Abstract excerpt

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of RNA polymerase (RNAP) in Mycobacterium leprae ( M. leprae ) contribute to phenotypic resistance to rifampin in...

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PMID: 32042379
DOI: 10.1016/j.csbj.2020.01.002

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