Article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

2023-04-08

Abstract excerpt

The term “druggability” describes the molecular properties of drugs or targets in pharmacological interventions and is commonly used in work involving drug development for clinical applications. There are no current analogues for this notion that quantify the drug-target interaction with respect to a given target variant’s sensitivity across a breadth of drugs in a panel, or a given drug’s range of effectiveness a...

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Literature Corpus work: 5b56cec4-67bb-5d43-ba29-32c0d90e2ca2
DOI: 10.1101/2023.04.08.536116

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