Article

Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in <i>Mycobacterium leprae</i>

2019-05-29

Abstract excerpt

<h4>ABSTRACT</h4> In contrast to the situation with tuberculosis, rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic methods. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations. The functional consequences of missense mutations within the β-subunit of RNA polymerase in Mycobacterium leprae ( M. leprae ) contribu...

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Literature Corpus work: c5a988ee-9b88-5f1e-85ae-5ed8cf22f062
DOI: 10.1101/654095

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