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Engineering Compact Base Editors by AlphaFold-Guided Mutation Scan and Escherichia coli-Based Tri-Selection.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2026

Gang Son Ryeo, Kim Goeun, Lee Jungjoon K

Abstract excerpt

APOBEC1-based cytosine base editors such as BE4max enable base conversion, but many alternative deaminases show low activity and cytotoxicity, especially when miniaturized for delivery. SsdAtox, a DNA deaminase toxin from Pseudomonas syringae that is two-thirds the size of APOBEC1, is attractive for compact base editors but, in native form, shows low C-to-T editing efficiency and high cytotoxicity. Guided by an...

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Identifiers

PMID: 41631734
DOI: 10.1002/advs.202516213
PMCID: PMC13067763

Genes

APOBEC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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