Article
Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities.
eLife - 21 Oct 2024
Zhang Honglei, Liu Chao, Wang Shuting, Wang Qing, Feng Xu, Jiang Huawei, Xiao Li, Luo Chao, Zhang Lu, Hou Fei, Zhou Minjun, Deng Zhiyong, Li Heng, Zhang Yong, Su Xiaosan, Li Gaofeng
Abstract excerpt
Air pollution significantly impacts lung cancer progression, but there is a lack of a comprehensive molecular characterization of clinical samples associated with air pollution. Here, we performed a proteogenomic analysis of lung adenocarcinoma (LUAD) in 169 female never-smokers from the Xuanwei area (XWLC cohort), where coal smoke is the primary contributor to the high lung cancer incidence. Genomic mutation...
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