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Mutational landscape induced by chronic exposure to environmental PM10 and PM2.5 in A549 lung epithelial cell.

Chemosphere - 1 Nov 2024

Quezada-Maldonado Ericka Marel, Cerrato-Izaguirre Dennis, Morales-Bárcenas Rocío, Bautista-Ocampo Yanueh, Santibáñez-Andrade Miguel, Quintana-Belmares Raúl, Chirino Yolanda I, Basurto-Lozada Patricia, Robles-Espinoza Carla Daniela, Sánchez-Pérez Yesennia, García-Cuellar Claudia M

Abstract excerpt

Exposure to particulate matter (PM) has been linked to an increased risk of multiple diseases, primarily lung cancer, through various molecular mechanisms. However, the mutagenic potential of PM remains unclear. This study aimed to provide a comprehensive description of genetic mutations and mutagenic signatures resulting from chronic exposure to PM10 or PM2.5. Using whole exome sequencing, we identified driver...

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PMID: 39551196
DOI: 10.1016/j.chemosphere.2024.143766

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