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Article

Cellular senescence and other age-related mechanisms in skeletal diseases

7 Jul 2025

Abstract excerpt

Cellular senescence and its senescence-associated secretory phenotype (SASP) represent a pivotal role in the development of skeletal diseases. Targeted elimination or rejuvenation of senescent cells has shown potential as a therapeutic strategy to reverse age-related skeletal senescence and promote bone regeneration. Meanwhile, other age-related mechanisms, involving altered cellular functions, impaired...

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Bone Metabolism and Diseases
Osteoarthritis Treatment and Mechanisms
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40623977
DOI: 10.1038/s41413-025-00448-7

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